Characteristics of optic neuropathy in Behçet disease

Acute optic neuropathy in Behçet disease.

PURPOSE To report a patient with Behcet disease presenting with acute optic neuropathy. METHODS A 47-year-old man was admitted to the authors' clinic owing to sudden visual loss in the left eye. Ophthalmologic and systemic examinations were performed. RESULTS Visual acuity was 4/10 in the left eye. Fundus examination demonstrated swollen optic disc with blurred margins. There was relative a...

Ischaemic optic neuropathy in pulseless disease.

Optic Neuropathy Associated with Castleman Disease

A 44-year-old woman with Castleman disease presented with acute visual loss in the left eye. A full ophthalmologic examination and imaging were performed. Visual acuity was 20/20 in the right eye and 20/100 in the left eye. Total dyschromatopsia, a relative afferent pupillary defect, and a cecocentral scotoma were observed in the left eye. Mild disc edema, without leaking during fluorescein ang...

Leber’s hereditary optic neuropathy with late disease onset: clinical and molecular characteristics of 20 patients

BACKGROUND Leber's hereditary optic neuropathy (LHON) is a mitochondrial disease that typically causes bilateral blindness in young men. Here we describe the clinical and molecular characteristics of 20 patients with disease onset after the age of 50 years (late onset-LHON). METHODS From a cohort of 251 affected and 277 unaffected LHON carriers, we identified 20 patients with onset of visual ...

Neuropathology of white matter disease in Leber's hereditary optic neuropathy.

Leber's hereditary optic neuropathy (LHON) is associated with point mutations in the mitochondrial DNA (mtDNA), coding for a mitochondrial respiratory chain complex I subunit. It is characterized by bilateral, usually sequential, optic neuropathy and may co-occur with multiple sclerosis-like white matter lesions. Despite repeated clinical reports including MRI and histopathological examination ...